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  • 當前位置:產品與服務 >替米沙坦
    替米沙坦

    基本信息
    化學名稱:4′-[4-甲基-6-(1-甲基-1H-苯并咪唑-2-基)-2-丙基-1H-苯并咪唑基甲基]聯苯基-2-羧酸
    分子式:C33H30N4O2
    分子量: 514.62
    CAS NO:144701-48-4
    質量標準:USP/ EP/ 國家標準, 可提供DMF/ CEP/ GMP。


     Specification

         According to European Pharmacopoeia 7.8

    Items

    Specification

    Results

    Appearance

    White or slightly yellowish crystalline powder

    White crystalline powder

    Solubility

    Should meet the requirement

    Conforms

    IR Identification

    Should correspond to the RS Infrared Absorption

    Correspond to the reference substance

    Appearance of solution

    Should meet the requirement

    Conforms

    Related substance

    Impurity A

    ≤0.15%

    0.05%

    Impurity B

    ≤0.15%

    0.02%

    Impurity C

    ≤0.2%

    0.03%

    Impurity D

    ≤0.2%

    0.05%

    Unspecified Ims.

    ≤0.1%

    0.06%

    Total

    ≤1.0%

    0.30%

    Residual solvents

    Methanol

    ≤0.3%

    Not detected

    Ethanol

    ≤0.5%

    0.031%

    Methylene dichloride

    ≤0.06%

    Not detected

    n-hexane

    ≤0.029%

    Not detected

    Acetic acid ethyl ester

    ≤0.5%

    Not detected

    Toluene

    ≤0.089%

    0.025%

    Acetic acid

    ≤0.5%

    0.036%

    Loss on drying

    ≤0.5%

    0.20%

    Sulphated ash

    ≤0.1%

    Conforms

    Melting point

        261 ºC -263 ºC

         261.1 ºC -262.2 ºC

    Particle size

        90% Less than 200um

         Conforms

    Assay

        99.0%~101.0%

         99.9%

    Conclusion

       It conforms to European Pharmacopoeia 7.0

    作用與用途:用于原發性高血壓的治療。

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